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Final Program


CRS Abstract Guide

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  • Tuesday, Jul 15th
    10:00 AM - 12:00 PM EDT
    Tech Session I: Nanomedicine and Nanoscale Delivery (Focus: Gene)
    Location: 121 B/C
    Chair: Simon Drescher, PD Dr (he/him/his) – Phospholipid Research Center
    Co-Chair: Cristina Fornaguera Puigvert, PhD (she/her/hers) – Institut Químic de Sarrià (IQS) - Universitat Ramon Llull (URL)
    Nanomedicine and Nanoscale DeliveryGene Delivery and Gene Editing
  • Tuesday, Jul 15th
    10:04 AM - 10:29 AM EDT
    Characterizing CRISPR-Cas ribonucleoprotein delivery with bioreducible polymer nanoparticles
    Location: 121 B/C
    Invited Speaker - Exceptional Abstract: Christopher L. Grigsby, PhD (he/him/his) – Queen's University Belfast
    Nanomedicine and Nanoscale DeliveryGene Delivery and Gene Editing
  • Tuesday, Jul 15th
    10:54 AM - 11:05 AM EDT
    Overcoming Chemoresistance in Colorectal Cancer by FcRn-Driven Nucleic Acid Delivery
    Location: 121 B/C
    Oral Abstract Speaker: Natália Teixeira, MSc – Instituto de Investigação e Inovação em Saúde (i3S)
    Nanomedicine and Nanoscale DeliveryGene Delivery and Gene Editing
  • Tuesday, Jul 15th
    11:27 AM - 11:38 AM EDT
    Targeted-LNPs capable of functional DNA delivery to T cells enable in vivo CAR-T generation
    Location: 121 B/C
    Oral Abstract Speaker: Daniel Murphy, PhD – Nanocell Therapeutics
    Nanomedicine and Nanoscale DeliveryGene Delivery and Gene Editing
  • Tuesday, Jul 15th
    2:00 PM - 4:00 PM EDT
    Tech Session II: Gene Delivery and Gene Editing I
    Location: 119 A
    Chair: Francesca Taraballi, PhD (she/her/hers) – Houston Methodist Research Institute
    Co-Chair: Michael Mitchell
    Gene Delivery and Gene Editing
    Sponsored By 
  • Tuesday, Jul 15th
    2:02 PM - 2:04 PM EDT
    XGen Introduction
    Location: 119 A
    Presenter: Rui Zhang
    Gene Delivery and Gene Editing
  • Tuesday, Jul 15th
    2:04 PM - 2:29 PM EDT
    Nature-inspired nanotechnology for RNA delivery to myeloid cells and bone marrow progenitors
    Location: 119 A
    Invited Speaker - Exceptional Abstract: Roy van der Meel, PhD – Eindhoven University of Technology
    Gene Delivery and Gene Editing
    Sponsored By 
  • Tuesday, Jul 15th
    2:29 PM - 2:54 PM EDT
    Development of SORT lipid nanoparticles (LNPs) for genome correction of disease-causing mutations
    Location: 119 A
    Invited Speaker - Exceptional Abstract: Daniel J. Siegwart, PhD – University of Texas Southwestern Medical Center
    Gene Delivery and Gene Editing
    Sponsored By 
  • Tuesday, Jul 15th
    2:54 PM - 3:05 PM EDT
    Cardiac-tropic Lipid Nanoparticles Provide Selective Vascularization After Myocardial Infarction
    Location: 119 A
    Oral Abstract Speaker: Junchao Xu (he/him/his) – university of pennsylvania
    Gene Delivery and Gene Editing
    Sponsored By 
  • Tuesday, Jul 15th
    3:05 PM - 3:16 PM EDT
    Targeting a novel oncogene with an azacitidine-based prodrug nanocarrier to elicit immunogenic cell death for advanced cancer therapy
    Location: 119 A
    Oral Abstract Speaker: Bei Zhang, MS (she/her/hers) – University of Pittsburgh
    Gene Delivery and Gene Editing
    Sponsored By 
  • Tuesday, Jul 15th
    3:16 PM - 3:27 PM EDT
    One-component Janus dendrimers: a novel platform for efficient mRNA vaccine delivery
    Location: 119 A
    Oral Abstract Speaker: Wook-Jin Park, Ph.D – University of Pennsylvania
    Gene Delivery and Gene Editing
    Sponsored By 
  • Tuesday, Jul 15th
    3:38 PM - 3:49 PM EDT
    Virus-Mimicking Nanoparticles for Precise Intracellular siRNA Delivery
    Location: 119 A
    Oral Abstract Speaker: Tong Wu, n/a – Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China
    Gene Delivery and Gene Editing
    Sponsored By 
  • Tuesday, Jul 15th
    3:49 PM - 4:00 PM EDT
    Unraveling endosomal escape: mechanistic insights into lipid nanoparticle-mediated RNA delivery
    Location: 119 A
    Local Chapter Speaker: Alice Spadea – MPI-CBG
    Gene Delivery and Gene Editing
    Sponsored By 
  • Wednesday, Jul 16th
    10:00 AM - 12:00 PM EDT
    Tech Session III: Gene Delivery and Gene Editing II
    Location: 119 A
    Chair: Guarav Sahay, PhD – Oregon State University
    Co-Chair: Yvonne Perrie, PhD (she/her/hers) – University of Strathclyde
    Gene Delivery and Gene Editing
  • Wednesday, Jul 16th
    10:04 AM - 10:29 AM EDT
    Enhanced pDNA Delivery Mediated by Backbone-Degradable RAFT Copolymers
    Location: 119 A
    Invited Speaker - Exceptional Abstract: Adam J. Gormley, PhD – Rutgers University
    Gene Delivery and Gene Editing
  • Wednesday, Jul 16th
    10:29 AM - 10:54 AM EDT
    DNA-loaded lipid nanoparticles (DNA-LNPs): a platform technology to treat common chronic diseases
    Location: 119 A
    Invited Speaker - Exceptional Abstract: Jacob Brenner, MD, PhD – University of Pennsylvania
    Gene Delivery and Gene Editing
  • Wednesday, Jul 16th
    10:54 AM - 11:05 AM EDT
    Lipid Nanoparticle Delivery for CRISPR Gene Editing in Primary Human T-cells
    Location: 119 A
    Oral Abstract Speaker: Joy J. Chen, BS – UC Berkeley
    Gene Delivery and Gene Editing
  • Wednesday, Jul 16th
    11:05 AM - 11:16 AM EDT
    Breaking Barriers: Stabilized Lipid Nanoparticles Transform Oral Nucleic Acid Delivery
    Location: 119 A
    Oral Abstract Speaker: Kanika Suri, PhD – Takeda Pharmaceuticals, Northeastern University
    Gene Delivery and Gene Editing
  • Wednesday, Jul 16th
    11:16 AM - 11:27 AM EDT
    The lipid nanoparticle shape and morphology affect the efficiency and duration of mRNA transfection
    Location: 119 A
    Oral Abstract Speaker: Sara Elsafy, MSc (she/her/hers) – RWTH Aachen University
    Gene Delivery and Gene Editing
  • Wednesday, Jul 16th
    11:27 AM - 11:38 AM EDT
    Optimization of Nanoparticle Delivery of Nucleic Acids to Cells using Poly(glycerol esters)
    Location: 119 A
    Oral Abstract Speaker: Brian P. Ginn, PhD (he/him/his) – Secant Group, LLC.
    Gene Delivery and Gene Editing
  • Wednesday, Jul 16th
    11:38 AM - 11:49 AM EDT
    Optimized lipid nanoparticles for CRISPR/Cas9 delivery: advancing gene editing in lung tumor cells
    Location: 119 A
    Oral Abstract Speaker: Simone Carneiro, PhD (she/her/hers) – Ludwig-Maximilians-University of Munich
    Gene Delivery and Gene Editing
  • Wednesday, Jul 16th
    2:00 PM - 4:00 PM EDT
    Tech Session IV: Nanomedicine and Nanoscale Delivery (Focus: Gene)
    Location: 120 B/C
    Chair: Marianne Ashford, PhD (she/her/hers) – AstraZeneca
    Co-Chair: Biana Godin, MPharm, PhD (she/her/hers) – Houston Methodist Research Institute
    Nanomedicine and Nanoscale DeliveryGene Delivery and Gene Editing
  • Wednesday, Jul 16th
    2:04 PM - 2:29 PM EDT
    Peptide-Lipid Conjugates for Enhancing mRNA-LNP Delivery and Colon Cancer Vaccines
    Location: 120 B/C
    Invited Speaker - Exceptional Abstract: Kuo-Ching Mei, PhD – Department of Molecular Pharmaceutics, College of Pharmacy, University of Utah
    Nanomedicine and Nanoscale DeliveryGene Delivery and Gene Editing
  • Wednesday, Jul 16th
    2:29 PM - 2:54 PM EDT
    Polymeric Mesoscale Nanoparticles Selectively Target Gene Therapies to the Kidneys
    Location: 120 B/C
    Invited Speaker - Exceptional Abstract: Ryan M. Williams, PhD – The City College of New York
    Nanomedicine and Nanoscale DeliveryGene Delivery and Gene Editing
  • Wednesday, Jul 16th
    2:54 PM - 3:05 PM EDT
    Pioneering intranasal siRNA-based nanovaccine
    Location: 120 B/C
    Speaker: Rita C. Acurcio – iMed.ULisboa, Faculty of Pharmacy, University of Lisbon
    Nanomedicine and Nanoscale DeliveryGene Delivery and Gene Editing
  • Wednesday, Jul 16th
    3:05 PM - 3:16 PM EDT
    Lipid stereochemistry of lipid nanoparticles significantly influences mRNA expression levels in vivo
    Location: 120 B/C
    Oral Abstract Speaker: Renzo Knol, - (he/him/his) – Leiden University
    Nanomedicine and Nanoscale DeliveryGene Delivery and Gene Editing
  • Wednesday, Jul 16th
    3:16 PM - 3:27 PM EDT
    Lipid-siRNA Organization Modulates the Intracellular Dynamics of Lipid Nanoparticles
    Location: 120 B/C
    Oral Abstract Speaker: Yulin Mo – University of Toronto
    Nanomedicine and Nanoscale DeliveryGene Delivery and Gene Editing
  • Wednesday, Jul 16th
    3:27 PM - 3:38 PM EDT
    Dual Centrifugation: A Novel Perspective on LNP Formulation Development
    Location: 120 B/C
    Oral Abstract Speaker: Valentin Bender (he/him/his) – University of Freiburg
    Nanomedicine and Nanoscale DeliveryGene Delivery and Gene Editing
  • Wednesday, Jul 16th
    3:38 PM - 3:49 PM EDT
    Precision Attack: GD2-Directed siRNA-Lipid Nanoparticles to Target Neuroblastoma’s Weak Spots
    Location: 120 B/C
    Oral Abstract Speaker: Amy Logan, PhD (she/her/hers) – Children's Cancer Institute Australia
    Nanomedicine and Nanoscale DeliveryGene Delivery and Gene Editing
  • Wednesday, Jul 16th
    3:49 PM - 4:00 PM EDT
    Targeting the lower regions of the lung; a novel platform for pulmonary mRNA delivery
    Location: 120 B/C
    Oral Abstract Speaker: Rachel Sun (she/her/hers) – Ernest Mario School of Pharmacy, Rutgers University
    Nanomedicine and Nanoscale DeliveryGene Delivery and Gene Editing
  • Thursday, Jul 17th
    10:00 AM - 12:00 PM EDT
    Tech Session V: Gene Delivery and Gene Editing III
    Location: 119 A
    Chair: Maria Kavallaris, PhD (she/her/hers) – Australian Centre for NanoMedicine, University of New South Wales
    Co-Chair: Dan Peer – Tel Aviv University
    Gene Delivery and Gene Editing
  • Thursday, Jul 17th
    10:04 AM - 10:29 AM EDT
    Evaluating the effects of PEGylated lipid shedding on targeted nanomedicines
    Location: 119 A
    Invited Speaker - Exceptional Abstract: Lisa Volpatti, PhD – Northwestern University
    Gene Delivery and Gene Editing
  • Thursday, Jul 17th
    10:29 AM - 10:54 AM EDT
    Engineer Lipid Nanoparticle Surface Hydrophobicity to Modulate Nano-Bio Interface and Enable Tissue-Selective mRNA Delivery
    Location: 119 A
    Invited Speaker - Exceptional Abstract: Fan Zhang, PhD – University of Florida
    Gene Delivery and Gene Editing
  • Thursday, Jul 17th
    10:54 AM - 11:05 AM EDT
    PBAE-Based Pulmonary siRNA Delivery to T-Cells: A Potential Approach for Asthma Therapy
    Location: 119 A
    Oral Abstract Speaker: An Ny Nguyen, RPh (she/her/hers) – Ludwig Maximilian University of Munich
    Gene Delivery and Gene Editing
  • Thursday, Jul 17th
    11:05 AM - 11:16 AM EDT
    Lipid nanoparticle-mediated metabolic reprogramming of dendritic cells for mRNA vaccines
    Location: 119 A
    Oral Abstract Speaker: Dongyoon Kim, PhD (he/him/his) – University of Pennsylvania
    Gene Delivery and Gene Editing
  • Thursday, Jul 17th
    11:16 AM - 11:27 AM EDT
    Advancing T cell therapy: mRNA nanocarriers optimization for ex vivo and in vivo T cell engineering
    Location: 119 A
    Oral Abstract Speaker: Elisa Battistini (she/her/hers) – University of Santiago de Compostela
    Gene Delivery and Gene Editing
  • Thursday, Jul 17th
    11:27 AM - 11:38 AM EDT
    Enhancing mRNA-lipid nanoparticle prediction via the language model and multi-task learning
    Location: 119 A
    Oral Abstract Speaker: YIYANG WU, ME – University of Macau
    Gene Delivery and Gene Editing
  • Thursday, Jul 17th
    11:38 AM - 11:49 AM EDT
    Microrobot-Assisted Delivery of Circular RNA-Lipid Nanoparticles to Treat Lung-Associated Diseases
    Location: 119 A
    Oral Abstract Speaker: Bianca M. Santana (she/her/hers) – University of Colorado Boulder
    Gene Delivery and Gene Editing
  • Thursday, Jul 17th
    11:49 AM - 12:00 PM EDT
    Multi-stage mixing creates high-efficiency core-then-shell DNA lipid nanoparticles
    Location: 119 A
    Oral Abstract Speaker: Jia Nong, PhD (she/her/hers) – University of Pennsylvania
    Gene Delivery and Gene Editing
  • Thursday, Jul 17th
    4:30 PM - 6:30 PM EDT
    Tech Session VI: Nanomedicine and Nanoscale Delivery (Focus: Gene)
    Location: 120 B/C
    Chair: Álvaro Somoza, PhD (he/him/his) – IMDEA Nanociencia
    Co-Chair: Roy van der Meel, PhD – Eindhoven University of Technology
    Nanomedicine and Nanoscale DeliveryGene Delivery and Gene Editing
  • Thursday, Jul 17th
    4:34 PM - 4:59 PM EDT
    Rational design of mRNA folding architecture to enhance protein production
    Location: 120 B/C
    Invited Speaker - Exceptional Abstract: Qianqian Ni, PhD (she/her/hers) – National University of Singapore
    Nanomedicine and Nanoscale DeliveryGene Delivery and Gene Editing
  • Thursday, Jul 17th
    4:59 PM - 5:24 PM EDT
    Tolerogenic mRNA-lipid nanoparticle vaccines for autoimmune disease
    Location: 120 B/C
    Invited Speaker: Jilian Melamed, PhD (she/they) – University of Pennsylvania
    Nanomedicine and Nanoscale DeliveryGene Delivery and Gene Editing
  • Thursday, Jul 17th
    5:24 PM - 5:35 PM EDT
    Hybrid polymer-lipid nanoparticles as innovative transfection vectors for microRNA delivery
    Location: 120 B/C
    Oral Abstract Speaker: Martina Coletto (she/her/hers) – Politecnico di Torino
    Nanomedicine and Nanoscale DeliveryGene Delivery and Gene Editing
  • Thursday, Jul 17th
    5:35 PM - 5:46 PM EDT
    Xkr8 Knockdown Enhances Chemotherapy Efficacy Through Modulating Tumor Immune Microenvironment
    Location: 120 B/C
    Oral Abstract Speaker: Chien-Yu Chen, MS (she/her/hers) – University of Pittsburgh
    Nanomedicine and Nanoscale DeliveryGene Delivery and Gene Editing
  • Thursday, Jul 17th
    5:46 PM - 5:57 PM EDT
    Dual-Shielding Approach for TNFα Silencing in Inflammatory Bowel Disease via Bioadhesive Microbeads
    Location: 120 B/C
    Oral Abstract Speaker: Valentina Marotti, Master’s Degree in Chemistry and Pharmaceutical Techniques – Université catholique de Louvain
    Nanomedicine and Nanoscale DeliveryGene Delivery and Gene Editing
  • Thursday, Jul 17th
    5:57 PM - 6:08 PM EDT
    Dual Zn2+/Cu2+ Chelation-Engineered Nanotherapeutics for DNA-Mitochondrial Disruption in TNBC
    Location: 120 B/C
    Oral Abstract Speaker: Kai Xiao, PhD (he/him/his) – Sichuan University
    Nanomedicine and Nanoscale DeliveryGene Delivery and Gene Editing
  • Thursday, Jul 17th
    6:08 PM - 6:19 PM EDT
    High-throughput screening of lipid nanoparticles for lung delivery of mRNA
    Location: 120 B/C
    Oral Abstract Speaker: Marco Túllio Alves (he/him/his) – Federal University of Minas Gerais
    Nanomedicine and Nanoscale DeliveryGene Delivery and Gene Editing
  • Thursday, Jul 17th
    6:19 PM - 6:30 PM EDT
    The modular platform to deliver bio-orthogonal macromolecular conjugates (BMCs) for therapeutic gene editing
    Location: 120 B/C
    Oral Abstract Speaker: Ning Wang, PhD – Memorial Sloan Kettering Cancer Center
    Nanomedicine and Nanoscale DeliveryGene Delivery and Gene Editing
  • Friday, Jul 18th
    8:00 AM - 10:00 AM EDT
    Tech Session VII: Gene Delivery and Gene Editing IV
    Location: 119 B
    Chair: Sara Elsafy, MSc (she/her/hers) – RWTH Aachen University
    Co-Chair: Mariah L. Arral, PhD (she/her/hers) – Tufts University
    Gene Delivery and Gene Editing
  • Friday, Jul 18th
    8:04 AM - 8:29 AM EDT
    NanoGhost: A Stem Cell-Based Off-the-Shelf Nano-Delivery Platform for Targeted Drug and Gene Therapy
    Location: 119 B
    Invited Speaker: Marcelle Machluf, PhD (she/her/hers) – Technion Israel Institute of Technology, Founder & Advisor NanoGhost Ltd., Israel, Osnat Bohana-Kashtan NanoGhots Ltd, Israel, Yonatan Malca NanoGhost Ltd, Israel
    Gene Delivery and Gene Editing
  • Friday, Jul 18th
    8:29 AM - 8:54 AM EDT
    Designing Next-Gen LNPs: Tools, Challenges, and Opportunities
    Location: 119 B
    Invited Speaker: Yvonne Perrie, PhD (she/her/hers) – University of Strathclyde
    Gene Delivery and Gene Editing
  • Friday, Jul 18th
    8:54 AM - 9:05 AM EDT
    Polymer lipids reduce anti-PEG antibody binding for repeated administration of mRNA therapeutics
    Location: 119 B
    Oral Abstract Speaker: Yufen Xiao, PhD – UT Southwestern Medical Center
    Gene Delivery and Gene Editing
  • Friday, Jul 18th
    9:05 AM - 9:16 AM EDT
    Degradable cyclic amino alcohol ionizable lipids as vectors for potent influenza mRNA vaccines
    Location: 119 B
    Oral Abstract Speaker: Akash Gupta, n/a – MIT
    Gene Delivery and Gene Editing
  • Friday, Jul 18th
    9:16 AM - 9:27 AM EDT
    Antibody-conjugated lipid nanoparticles to enhance extrahepatic nucleic acid delivery
    Location: 119 B
    Oral Abstract Speaker: Sanjib Saha, PhD (he/him/his) – AstraZeneca Pharmaceuticals LP
    Gene Delivery and Gene Editing
  • Friday, Jul 18th
    9:27 AM - 9:38 AM EDT
    Boosting CAR T cells with Advanced Adjuvant Cancer Nanovaccines
    Location: 119 B
    Oral Abstract Speaker: Flavia Sousa, PhD (she/her/hers) – University of Groningen
    Gene Delivery and Gene Editing
  • Friday, Jul 18th
    9:38 AM - 9:49 AM EDT
    An Optimized Polymeric Delivery Platform for Pulmonary mRNA Vaccines
    Location: 119 B
    Oral Abstract Speaker: Min Jiang, Master in Pharmacy – Ludwig-Maximilians-Universität Münc
    Gene Delivery and Gene Editing
  • Friday, Jul 18th
    9:49 AM - 10:00 AM EDT
    In vivo nucleic acid targeted delivery in bone-marrow via antibody conjugated lipid nanoparticles
    Location: 119 B
    Oral Abstract Speaker: Sabrina Khan – AstraZeneca
    Gene Delivery and Gene Editing