(102) Local Inflammation Response of Salbutamol Formulations on ex-vivo Mouse Skin
Introduction: Salbutamol is a widely used drug for the treatment of bronchial diseases like asthma with studies of transdermal application [1]. In addition, salbutamol is also a promising therapeutic agent for obesity as it is able to promote thermogenesis [2]. To ensure the safety of topical application, it is necessary to evaluate the local inflammation on the skin. In this study, the local skin sensitivity of salbutamol was investigated in different solvents, some of which also have penetration-enhancing properties and are commonly used in formulations for the skin.
Learning Objectives:
Understanding the suitability of ex vivo mice skin for inflammation testing
Evaluation of the differences between different solvents in the mRNA expression of interleukins
