(106) 3D In Vitro Models of Osteosarcoma: A Novel Hydrogel-Scaffold System for Therapeutic Research

Osteosarcoma (OS) is the most common malignant bone tumor affecting children, adolescents, and young adults. While standard treatments, including surgery and chemotherapy, have improved the 5-year survival rate to 66%, therapy resistance, recurrence, and adverse side effects remain major challenges. This underscores the need for innovative treatments. OS malignancy is strongly influenced by its complex tumor microenvironment, which includes a small population of Cancer Stem Cells (CSCs) with self-renewing and pluripotent capabilities.