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Artificial Intelligence and Predictive Models

(109) Target-mediated drug disposition modeling of nonlinear pharmacokinetics in GLP-1 receptor agonists

Introduction:

Semaglutide and liraglutide are glucagon-like peptide-1 (GLP-1) receptor agonists used to treat type 2 diabetes and obesity. Despite their shared mechanism of action, they exhibit distinct pharmacokinetic profiles. Target-mediated drug disposition (TMDD) occurs when a drug binds with high affinity to a specific receptor, leading to nonlinear pharmacokinetics. This study aimed to develop a TMDD model to describe and compare the pharmacokinetic characteristics of semaglutide and liraglutide.

Learning Objectives:

  • To evaluate nonlinear pharmacokinetic behaviors of semaglutide and liraglutide using a TMDD model.
Soyoung Shin – College of Pharmacy, Chung-Ang University; Beom Soo Shin – School of Pharmacy, Sungkyunkwan University