(116) Exploiting Metabolite-Presenting Molecules for Targeted Therapies
Introduction: MHC class I-related protein (MR1) is a ubiquitously expressed, low polymorphic antigen-presenting molecule conserved across mammalian species. It uniquely presents metabolites to unconventional T cells (MR1Ts), playing a key role in immunity, cancer and autoimmune responses. Leveraging this, we are developing a "Dynamic Targeting" strategy that uses peptides that bind to specific MR1-metabolite complexes for precise drug delivery to diseased cells based on their unique metabolic profiles. This holds great promise for treating infectious diseases and other conditions with altered metabolism.
Learning Objectives:
Explore whether the dynamic targeting approach can be useful for their research.
Develop a drug delivery tool that can target diseased cells through their metabolic signature.
Víctor Mejías – PhD Student, Institute for Bioengineering of Catalonia (IBEC); José Pedro Loureiro – PhD Student, University of Basel; Joana Fort – Research Associate, Institute for Research in Biomedicine (IRB Barcelona); Gennaro De Libero – Full Professor, University of Basel; Manuel Palacín – Full Professor, Institute for Research in Biomedicine (IRB Barcelona); Giuseppe Battaglia – ICREA Professor, Institute for Bioengineering of Catalonia (IBEC)
