(122) Bioinspired lipoprotein-mimetic nanocarriers: Tackling drug solubility and permeability challenges

Introduction: Natural lipoproteins possess a distinctive core-shell architecture with a lipophilic inner phase, ideal for encapsulating poorly bioavailable drugs. This structural design facilitates the solubilization of hydrophobic actives, and critically enhances their permeability over cellular barriers. Additionally, the high biocompatibility and capacity for functionalization turn them into a promising tool for targeted drug delivery. Using them as a blueprint, we systematically developed, characterized, and evaluated different biomimetic formulations regarding their drug delivery efficiency.