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Bioengineering (Focus Group – BE)

(124) Microfluidic Fabrication of Alginate-PEGDGE Hydrogel Microspheres for Drug Delivery and Cell Therapy

Introduction: Several methods for producing hydrogel microspheres, including mechanical agitation and extrusion have been described. However, microfluidics is popular due to its high control over the size and shape of microspheres and high encapsulation efficiency. PEGDGE is a widely used crosslinking that enhances hydrogels' mechanical properties and stability. The reaction between sodium alginate and PEGDGE can be tailored to meet specific biomedical requirements. This work aims to form hydrogel microspheres to encapsulate tumor cells, stimulating the immune system to recognize and fight cancer cells.

Learning Objectives:

  • Understanding of the chemical properties and reactivity of alginate and PEGDGE.
  • Optimize pH, temperature, and reactant concentrations to achieve desired hydrogel properties.
  • Learn microfluidics principles and their application in producing uniform microspheres