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Bioengineering (Focus Group – BE)

(125) Macrophage-Mediated Delivery of Focused Ultrasound-Activated Nanocarriers for Triggered Drug Release

Introduction: Systemic drug delivery is often hindered by off-target effects and non-specific distribution. Focused ultrasound-mediated drug delivery, combined with nanoparticle-based systems, offers controlled release of encapsulated drugs directly at target site (1). Additionally, the use of immune cells that innately cross biological barriers introduces a relatively underexplored strategy for delivering therapeutics to inaccessible regions and disease targets. Here, we investigated the use of macrophages as carriers for FUS-responsive nanoparticles and their triggered release in tumor microenvironment.

Learning Objectives:

  • Understand the formulation process of PLGA-PEG nanoparticles for curcumin and PFOB encapsulation.
  • Explain the role of macrophage carriers in targeted drug delivery to tumor sites.
  • Evaluate ultrasound-triggered nanoparticles for controlled, targeted drug release effectiveness.