(128) Development of a microfluidic chip for efficient lipid formulation discovery of lipid nanoparticles

Introduction: Exosomes are gaining attention as promising biologics due to their biocompatibility, but their medical use is limited by heterogeneity and scalability. [1][2] To address this, studies on lipid nanoparticles (LNPs) mimicking the properties of exosomes have emerged. Since the lipid formulation of LNPs varies depending on the parental cell types of exosomes to be mimicked and the target disease, optimizing LNP formulations is essential.[3] Due to the time-intensive feature of manual processes, we developed a microfluidic chip to achieve optimal lipid formulations more efficiently and rapidly.