(131) Development of a solid-phase synthetic approach for triazine-based lipids
Introduction: Ionizable cationic lipids have significantly advanced lipid nanoparticle (LNP)-mediated drug, gene, and vaccine delivery, enabling improved transfection efficiency and biocompatibility (1). However, efficient synthetic approaches to achieve compositionally diverse libraries remain limited by synthetic challenges (2). Building on prior solution-phase synthesis of triazine-based lipids with unique properties and transfection efficiency, this study employs a solid-phase approach to rapidly generate diverse lipids for structure-activity studies to optimize in vitro and in vivo performance.
Learning Objectives:
Demonstrate solid-phase synthetic strategy of triazine lipids using cyanuric chloride as the linker
Evaluate how headgroup structure affects yield and conversion in triazine lipid synthesis
Describe how tail variation supports structure-activity studies for mRNA delivery optimization
