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Bioengineering (Focus Group – BE)

(132) Multimodal evaluation of a porous HA/β-TCP scaffold for bone repair and localized therapy in rats.

Introduction:

Large bone defects represent a significant clinical challenge by causing extended healing times (1), diminished functionality (2), and elevated complication risks (3). Multifunctional biomaterials that combine bone regeneration, controlled bioresorption, and localized drug delivery offer a promising solution. These innovative materials not only support effective bone repair but also address secondary issues such as infection control, diabetic bone healing, and targeted chemotherapy for bone tumors, ultimately improving patient outcomes. This approach could revolutionize bone repair.

Learning Objectives:

  • create and stabilize critical-sized long bone defects in rats for the evaluation of biomaterials.
  • gain proficiency in methodologies for evaluating scaffold performance in vivo.