(134) Cryoshocked T Lymphocytes (CSTLs) for Enhanced Delivery of Chemotherapeutics to the Lymph Node
Introduction: The spread of metastatic cells to draining lymph nodes (LNs) is a common and threatening progression of cancer that can lead to the advancement of disease and significant dysregulation of systemic immune responses1,2. The LN is an innately isolated organ resulting in extremely poor penetration of most systemically administered therapeutics, resulting in minimal treatment efficacy3-5. To overcome this gap, we have developed a T-cell mimetic delivery vehicle (CSTL) to deliver chemotherapeutic payloads using a Trojan-horse strategy, resulting in enhanced LN targeting and local sustained release.
Learning Objectives:
Understand the design rules of a novel cell-mimetic delivery platform
Evaluate a lymph node-targeted delivery system for improved uptake of chemotherapeutics
Assess the differences in biodistribution, off-target accumulation, and retention of cisplatin
