(137) Dendritic particles with nanostructured tendrils for adhesion and drug release to bladder cancers

Bladder cancer remains a leading cause of cancer-related mortality, yet current intravesical drug delivery methods suffer from limited retention in the bladder. We describe a simple method for manufacturing soft dendritic particles (SDPs) with nanostructured tendrils designed to enhance adhesion to epithelial tissues. The SDPs are encased in a hydrogel, enabling precise deposition through extrusion. SDPs encapsulate clinically relevant drugs, demonstrating enhanced cancer cell killing in vitro. In murine models, SDPs instilled into tumor-bearing bladders trigger robust immune cell responses.