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Bioengineering (Focus Group – BE)

(138) Kidnapper SA-Biosomes for alveolar macrophages targeting for managing pulmonary inflammation.

Introduction:

Pulmonary inflammation is triggered by pathogens or irritants, with pro-inflammatory cytokines recruiting immune cells like macrophages, neutrophils, and lymphocytes. Macrophages detect pathogens, secrete cytokines, and regulate the response, but dysregulation can damage tissues. Nanoparticles can modulate inflammation and aid recovery. This study developed biomimetic hybrid nanoparticles with cytokine receptors and sialic acid, evaluating their in vitro performance.

Learning Objectives:

  • Understand the role of sialic acid in enhancing nanoparticle targeting and inflammatory modulation.
  • Explore the potential of biomimetic nanoparticles in managing pulmonary inflammatory processes.
  • Analyze the capacity of cytokine capture by Biosomes (hybrid nanoparticles).