(147) GPNMB as an Orthobiologic for Bone Regeneration and Spinal Fusion for an Osteoporotic Rat Model
Introduction: Osteoinductive agents are essential for bone healing in orthopaedic procedures. Although autogenous bone grafting is the gold standard, it is limited by infection, pain, and fractures. Osteoactivin (GPNMB), a transmembrane glycoprotein, is a promising orthobiologic that promotes osteoblast differentiation, matrix mineralization, and bone formation while reducing inflammation. This study evaluates the potential role of GPNMB in spinal fusion surgery using an FDA-approved collagen sponge and a postmenopausal osteoporotic rat model to assess its clinical potential for enhanced bone repair.
Learning Objectives:
1) To assess the release profile of the rGPNMP.
2) To evaluate the orthobiolgie response of GPNMB in spinal fusion.
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Shahabeddin Yazdanpanah – MD student, NEOMED; Gabrielle Robinson – Ph.D student, NEOMED; Trinity Kronk – MD-PhD student, NEOMED; Mark Villers – Student, NEOMED; Thomas Mbimba – PhD-student, NEOMED; Scott McDermott – MD surgeon, NEOMED; Moses Oyewumi – Associate Professor, NEOMED; Fayez F. Safadi1 Safadi – Professor, NEOMED
