(157) Microfluidic formulations of Non Ionic Surfactant Vesicles

Non-Ionic Surfactant Vesicles (NISVs) are a flexible drug delivery and vaccine platform. They are formed from a synthetic, non-ionic surfactants and can entrap a variety of drug classes. They are similar to liposomes, but are more stable and less toxic due to the absence of phospholipids. There are a variety of ways to manufacture NISVs including film hydration, sonication and melt method. Traditionally we have focused on the melt method however, moving the formulation to a microfluidics platform to allow for larger production capacity has required additional optimization and characterization.