(159) Exploring Substrate Stiffness and YAP/TAZ Pathways in Non-Viral Gene Delivery Applications
Introduction: Non-viral gene delivery systems hold great promise for therapeutic applications, but their efficiency remains limited by various barriers, including cellular uptake and nuclear entry [1]. This study investigates how substrate stiffness influences non-viral gene delivery by modulating YAP/TAZ mechanotransduction pathways. These pathways are pivotal in cellular adaptation to mechanical cues, thus potentially directly impacting transfection efficiency (TE) [2].
Learning Objectives:
Participants will understand the role of substrate stiffness on mechanotransduction and genedelivery
Upon completion, participants will be able to explain YAP/TAZ's role in substrate stiffness and TE
Participants will understand the importance of biomaterials design for optimizing gene delivery
