(169) Development of a Cationic Light-Responsive Polymer for Enhanced Intranasal Gene Delivery
Introduction: Intranasal (IN) drug delivery is a promising method for immune activation due to the nasal cavity's rich network of lymph nodes and antigen-presenting cells. However, mucus entrapment and endosomal degradation hinder gene delivery. To overcome these barriers, we developed a Cationic Light-responsive polymer (CLP) that enhances mucosal penetration, generates reactive oxygen species (ROS) for endosomal escape, and boosts immune responses. This platform shows great potential for gene therapy and vaccine delivery via IN administration.
Learning Objectives:
Understand the challenges of intranasal gene delivery and strategies to overcome them.
Learn how photo-responsive polymers enhance mucosal penetration and endosomal escape.
Recognize the potential of ROS generation in boosting immune responses for gene therapy.
Hayoon Jeong – Senior Researcher, Dental Research Institute, Seoul National University, Republic of Korea; Hongjae Kim – Ph. D. Candidates, Department of BioMedical-Chemical Engineering, Department of Biotechnology, the Catholic University of Korea, Republic of Korea; YoungA Kim – Ph.D. candidate, Department of BioMedical-Chemical Engineering, Department of Biotechnology, the Catholic University of Korea, Republic of Korea; KyoungSub Kim – assistant professor, Department of BioMedical-Chemical Engineering, Department of Biotechnology, the Catholic University of Korea, Republic of Korea; Kun Na – professor, Department of BioMedical-Chemical Engineering, Department of Biotechnology, the Catholic University of Korea, Republic of Korea
