(173) Synthetic bacterial spores for mRNA targeting and delivery

Introduction: RNA therapy shows promise for treating various diseases, but effective delivery, particularly beyond the liver and kidneys, remains a challenge. To address this, we propose using synthetic bacterial spore-like particles (SSHELs) [1]. These biocompatible particles selectively bind to HER2-positive ovarian cancer in vitro and in vivo, accumulate in tumors, and deliver therapeutic drugs [2]. In this study, we investigate whether SSHELs can effectively deliver mRNA to HER2-positive cancer cells.