(175) Microfluidic Erythrocyte-Camouflaged Chitosan Nanoparticles for Nucleic Acid Delivery

Introduction: Gene therapy holds immense potential for treating a wide range of diseases but delivering nucleic acids safely and effectively remains a major challenge [1]. These molecules are prone to rapid degradation and nanoparticles (NP) designed for their delivery are often cleared by the immune system [2]. In this study, chitosan-based DNA NP coated with red blood cell membranes (RBCm) were formulated and prepared by microfluidic technique, through a scalable solution that enhances stability, prolongs circulation time and paves the way for more effective gene therapy applications.