Skip to main content
CRS 2025 Annual Meeting & Exposition Main banner
Rate Poster

Gene Delivery and Gene Editing (Focus Group - GDGE)

(182) Ultra-Small Nanomaterial for Co-delivery of Antisense Oligonucleotides to Treat Glioblastoma

Introduction: Glioblastoma (GBM) is one of the most common, aggressive, lethal, and malignant forms of CNS tumour with high mortality, poor prognosis, and complex heterogeneity. Out of the pool of miRNAs, two specific miRNAs, miRNA-21 and miRNA-210, are aberrantly expressed in GBM and act as oncogenic miRNAs. Designing ultra-small mesoporous silica nanoparticles (USMPs) can not only protect the nucleic acid cargo from degradation by serum nucleases, but post-surface modification, they can efficiently deliver these therapeutic nucleotides into the heterogeneous tumour microenvironment of GBM.

Learning Objectives:

  • Understand the synthesis and characterization of ultra-small mesoporous silica nanoparticles (USMP).
  • Design the surface modification strategies for complexation of USMP with anti-miRs.
  • Evaluate the delivery of the USMP-anti-miR complex in the GBM cell line and across the 2D BBB model.