(189) Design of improved and safer ionizable lipids for next-generation nanomedicines
Introduction: Messenger RNAs (mRNAs) represent a versatile therapeutic modality able to address a wide range of unmet medical needs [1]. Lipid nanoparticles (LNP) are the most advanced carriers for RNA delivery, with ionizable lipids being the critical component in designing improved RNA therapies [2]. The design of ionizable lipids remains an empirical and labor-intensive process. impairing the advance of next generation therapies. In this study, we utilized a combinatorial chemistry approach to design new libraries of novel ionizable lipids for successful mRNA lipid nanoparticle delivery.
Learning Objectives:
Upon completion, participant will be able to understand the role of ionizable lipids in targeting
Upon completion, participant will be able to evaluate combinatorial chemistry techniques
Upon completion, participant will be able to reflect on structure-function relationship
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