(193) Optimization of mRNA structure for the enhancement of stability and translational activity

mRNA has received significant attention in the fields of gene therapy and vaccine development because it can serve as a multi-purpose platform. However, mRNA is inherently unstable due to decapping and deadenylation, leading to a short half-life and reduced translational activity. Therefore, in order to increase the translation efficiency of mRNA, we studied mRNA structures that minimize immunogenicity and improve stability.