(213) Surface-Capped Protein Nanoparticles for Non-Viral Gene Delivery
Introduction: Modifying or correcting disease-causing genetic mutations through the delivery of nucleic acids is of high interest. . Nanoparticles (NPs) have significantly advanced the field of non-viral gene delivery, however, clinical translation remains challenging for most NP systems. These challenges are predominantly due to poor NP stability, inefficient nucleic acid encapsulation, delivery to the desired cells, and effective transfection within the cells. This work explores the surface stabilization of protein nanoparticles with polycations to improve NP stability and enhance transfection of pDNA.
Learning Objectives:
Assess how scPNPs enhance the transfection efficiency of large nucleic acids
