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Global Health, Special Population, and Women’s Health

(217) Understanding Depot Formation of Long-Acting Injectable Suspensions: A Physicochemical Perspective

Introduction: Long-acting injectable (LAI) suspensions are subcutaneous (SQ) or intramuscular (IM) drug products designed for controlled delivery that form drug depots at the injection site [1,2]. Depot formation and any subsequent physicochemical changes at the SQ/IM site are poorly understood. This is a critical knowledge gap as depot formation likely affects in vivo drug release. This study investigates the physicochemical characteristics of these depot including tissue analysis to elucidate in vivo drug release dynamics.

Learning Objectives:

  • Physicochemical understanding of depot formation will aid the development of Long acting injectables
  • Understanding of depot formation will aid development of PBPK model for long acting injectables
  • Development of PBPK model for long acting injectables will aid development of generic equivalents