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Global Health, Special Population, and Women’s Health

(221) Electrospun Nanofibers for Dual Probiotic and Antibiotic Delivery Targeting Bacterial Vaginosis

Introduction: Bacterial vaginosis (BV) is characterized by replacement of vaginal Lactobacilli with other anaerobes. Metronidazole (MET) is the standard treatment, but recurrence rates exceed 50%. Probiotic Lactobacillus reduces these rates by producing antimicrobial agents, but frequent administration impacts patient compliance. For the first time, this study evaluates PEO/PLGA electrospun nanofibers as vehicles for dual delivery of MET and sustained L. crispatus, detailing the fiber properties and their ability to both deplete anaerobes and release probiotic.

Learning Objectives:

  • Using electrospinning technology, formulate PEO/PLGA nanofibers incorporating MET and L crispatus.
  • Characterize the physical properties of dual-loaded PEO/PLGA nanofibers.
  • Describe the MET and L. crispatus release profiles of dual-loaded PEO/PLGA nanofibers.