(224) Enzyme-activated MRI contrast agent for tumor-specific gadolinium delivery
Introduction: Metal chelator-based contrast agents are commonly used for cancer diagnosis as tumor-targeting tools. While approved chelators offer excellent contrast in magnetic resonance imaging (MRI), they often require large doses due to fast clearance and non-specific accumulation throughout the body, which can pose safety risks. This study introduces an enzyme-responsive metal delivery system, where an enzyme overexpressed in the tumor microenvironment selectively triggers the uptake of gadolinium (Gd) by the tumor.
Learning Objectives:
This study introduces an enzyme-responsive metal delivery system
a highly specific theranostic agent for MRI-guided radiotherapy
