(225) Advancing Cancer Imaging and Therapy Through Peptide PET Tracers Targeting c-Met

Aberrant hepatocyte growth factor receptor (c-Met) expression is involved in the development and metastatic progression of several tumour types, and its overexpression is associated with increasing invasiveness of cancer cells, drug resistance and poor clinical outcome. The knowledge of c-Met expression in real-time will be helpful in the diagnosis and in the monitoring of response to therapy. In this context, we propose, evaluate and select small peptides PET tracers for c-Met imaging as powerful tools for the detection, monitoring and treatment of the most common and lethal cancers.