(231) Metformin-loaded rod-shaped iron(III) carboxylate biomimetic MOFs for antibacterial immunotherapy
Introduction: Tuberculosis (TB) is the leading cause of death from a single infectious agent. Its treatment faces challenges, including the emergence of multidrug-resistant strains. Although TB affects a quarter of the world’s population, only 5-10% develop active TB, making immune modulation a promising strategy for its eradication. This study examines the immunotherapeutic potential of metformin encapsulated in rod-shaped microporous biomimetic, biocompatible and biodegradable iron(III) carboxylate-based Metal Organic Frameworks (MOFs) for TB eradication in Mycobacterium smegmatis (M. smegmatis) TB model.
Learning Objectives:
Understand the physicochemical properties of various MIL-53 formations.
Understand the immune modulatory effect of metformin in M. smegmatis TB model.
Understand the impact of metformin release kinetics from MIL-53 on its in vitro activity.
Zhihao Yu – PhD student, , Ecole Normale Supérieure de Paris, France; Mathilde Lepoitevin@ens.fr, PhD – Assistant professor, Ecole Normale Supérieure de Paris, France; Christian Serre – CNRS research director, Ecole Normale Supérieure de Paris, France; Joshua Reineke, PhD – Associate professor, South Dakota State University
