(234) Sustained Delivery Of Immunoglobulin (IgG) Through Biodegradable Poly(Orthoester) Solid Implant

Introduction: Certain chronic diseases require long-term infusion treatments or frequent bolus injections of large proteins such as monoclonal antibodies. High treatment frequency often leads to compliance issues and increased patient treatment burden. To address these issues, a drug delivery system is needed that can provide sustained delivery of large proteins for over six months such as drug eluting solid implants. This contribution explores the development and processing of a polyorthoester (POE) biodegradable polymer-based drug eluting implants for the release of immunoglobulin (IgG) for six months.