(248) Polymorphism and crystallinity variation of loratadine in polymeric delivery systems

Introduction: The polymorphism and crystallinity of drugs can significantly influence their physicochemical properties and pharmaceutical performance. Loratadine (LAD), a potent allergy-relief drug, has been found to exhibit one amorphous and two crystalline polymorphs [1]. In this study, we evaluated the morphology of LAD when incorporated into three different polymers using film casting.

David Shafiei – Master student, Brown university; Jelynn Tatad – Master student, Brown university; Zakhar Lyakhovych – PhD student, Brown university; Anthony Comeau – Research assiciate, Brown university; Vera Fonseca – Lab manager, Brown university; Tejal Desai – Professor, Brown university; Edith Mathiowitz – Professor, Brown university