(251) Twin Screw Extrusion Process Design and Die Modeling for Directly Extruded Implants.

Introduction: Developed approximately 100 years ago for natural rubber and plastics applications, processes via twin screw extrusion (TSE) now generate some of the most cutting-edge drug delivery systems available. Progress has been made toward improving direct and continuous extrusion of ocular, hormonal, and multi-layer implant devices using system design and detailed modeling of die components. The typical small batch sizes associated with several implant devices (50 g/batch) can be processed with approximately 90% yield.