(263) Development of a new spray drying method for sustained release of VEGF from marine biopolymers

Introduction: Vascular endothelial growth factor (VEGF) can be utilized to promote angiogenesis in varying therapeutic approaches [1]. However, for optimal results, VEGF release needs to be controlled in a spatial and temporal manner [2]. Spray drying has already been investigated for the encapsulation of VEGF into alginate [3]. The resulting particles can be crosslinked CaCl2 to slow down release of VEGF after an initial burst. Alternatively, a three fluid nozzle can be employed for in situ crosslinking and its benefit is assessed in this study.