Skip to main content
CRS 2025 Annual Meeting & Exposition Main banner
Rate Poster

Manufacturing and Process Scale-Up

(269) Optimizing PAT: Refractometer in Continuous Manufacturing of Lipid-Based Therapeutics

Introduction:

Continuous manufacturing (CM) of lipid-based therapeutics makes use of process analytical technology (PAT) to ensure critical quality attributes (CQAs). Process refractometers enable inline concentration monitoring, particularly for cryoprotectants. While refractive index (nD) is well-characterized for single-component systems, multi-component systems remain understudied. This work investigates interactions between formulation components and process parameters to enhance refractometry as a PAT tool, improving the efficiency and reliability of CM for lipid-based therapeutics.

Learning Objectives:

  • Understand the role of PAT in continuous manufacturing of lipid-based therapeutics.
  • Recognize formulation and process parameter factors affecting inline refractometry.
  • Learn about formulation-specific calibrations that affect concentration calculations.

    Poster Presenter(s)

  • Luke Burroughs

    Graduate Student
    University of Connecticut
    Storrs, Connecticut, United States