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Manufacturing and Process Scale-Up

(274) Microstructural and compositional analysis of dexamethasone-loaded poly(lactide-co-glycolide) rods

Introduction:

Poly(lactide-co-glycolide) (PLGA) has been used widely for developing long-acting injectable formulations, including Ozurdex®, a miniature-size implant for ocular delivery of dexamethasone for 3 months. Previously, the sequential exposure of semi-solvents and subsequent morphological evaluations by SAVI were developed to elucidate the internal microstructural characteristics of PLGA microparticles [1]. The current work applied the SAVI method to study dexamethasone-loaded mini-rods.

Learning Objectives:

  • understand the relationship between polymer-solvent vapor interaction and the polymer utilized.
  • appreciate the impact of microstructural arrangement on the properties of drug-loaded implants.
  • conceptualize the relationship between composition and release properties of PLGA mini-rods.