(277) Astrocyte Membrane-Coated Nanoparticles: A Targeted Therapeutic Strategy for Glioblastoma Treatment
Introduction: Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor and presents significant clinical challenges due to its infiltrative nature and resistance to conventional therapies [1]. GBM cell relays on the supply of cholesterol from astrocytes for survival, therefore we hypothesize that nanoparticles mimicking astrocyte derived vesicles could be a potential drug delivery system for GBM treatment [2,3,4].
Learning Objectives:
Define the incorporation of astrocyte membranes into lipid nanoparticles for targeted drug delivery.
Describe the effect of astrocyte membrane concentrations on nanoparticle uptake in cell lines.
Demonstrate TEM use in confirming nanoparticle formation and membrane coating.
