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Nanomedicine and Nanoscale Delivery (Focus Group - NND)

(280) Hyaluronic Acid-Functionalised pH-Responsive Nano-cocktails Targeting Breast Cancer Stem Cells

Introduction: Cancer stem cells (CSCs) are highly resistant to treatment and are considered vital contributors to metastasis and recurrence in breast cancer (BC) [1]. Combining drugs that target multiple pathways has shown the potential to eradicate CSCs [2]. pH-sensitive liposomes (pSL) functionalised with hyaluronic acid (HA) enhance specificity by targeting CD44 receptors overexpressed on CSCs, improving therapeutic efficacy [3]. This study aims to evaluate HA-functionlised pSL loaded with Doxorubicin (DOX) and Bufalin (BUF) to target HER2+ BCSCs, thus potentially reducing metastasis and recurrence.

Learning Objectives:

  • Investigate CD44-targeted pH-sensitive liposomes for enhanced drug accumulation in cancer tissue.
  • Evaluate the synergistic effects of two anticancer drugs within the liposomal formulation.
  • Assess the efficacy of the developed formulation in 2D and 3D cancer models.