(283) Liposomal Delivery of Caffeine and Cafestol for Enhanced Skin Absorption

Introduction: Green coffee beans offer health benefits like antioxidant and anti-inflammatory properties [1]. Key components include alkaloids such as caffeine and diterpenes, e.g., cafestol [2]. These compounds show promise for skin conditions like acne, but caffeine has poor skin penetration, while cafestol's hydrophobicity and instability pose challenges for formulation [5]. This study aims to develop liposomal formulations to enhance caffeine and cafestol skin delivery. Liposomes offer improved skin penetration, protection from degradation, controlled release, and enhanced biocompatibility.