(295) Inducing Mucosal Immunity in IPV Immunization Using Retinoid Derivative-Encapsulated Nanoparticles

Introduction: Enteric pathogens pose a significant global health challenge (1). Effective protection against these pathogens necessitates the induction of robust mucosal immunity within the GI tract (2). Therefore, there is a need to develop novel mucosal adjuvants (3). All-trans-retinoic acid (atRA) has been investigated as an adjuvant to enhance intestinal mucosal immunity via gut-homing imprinting (4). To address the challenge of eliciting intestinal mucosal immunity following parenteral immunization of IPV, we developed retinoid derivative-encapsulated nanoparticles as an innovative mucosal adjuvant.