(299) The potential effect of L-carnosine loaded hyalurosomes as a novel anti-aging nano-cosmeceutical gel

Introduction: Skin aging induced by chronic exposure to ultraviolet (UV) radiation, requires innovative nano-cosmeceutical formulations to counteract this damage. Better therapeutic outcomes can be achieved by incorporating bioactive excipients as hyaluronic acid that can reduce wrinkles and promote keratinocyte proliferation. Thus, hyalurosomes (HS) were the chosen nano-formulation. HS was further loaded with L-carnosine (CN), a challenging dipeptide with reported antioxidant and anti-inflammatory properties. This novel nano-system would overcome the hydrophilic nature of CN and enhance its skin permeation