(301) Drug-loaded cyclodextrin-based polymers to treat pulmonary infections
Introduction: Infections caused by drug-resistant pathogens pose a global healthcare challenge that requires innovative treatment solutions [1]. Cyclodextrin (CD)-based polymers enhance drug solubility, stability, and controlled release by utilizing the host-guest complexation properties of CDs [2-4]. This study focuses on developing water-soluble CD polymers to encapsulate hydrophobic antibiotics to be delivered specifically to the lungs. We investigated the encapsulation of linezolid, a poorly water-soluble antibiotic commonly used to treat infections caused by drug-resistant gram-positive bacteria.
Learning Objectives:
Design cyclodextrin-based delivery systems capable of spontaneously solubilizing hydrophobic drugs.
Understand the impact of molecular weight on drug association.
Ruxandra Gref – Research Director, Université Paris-Saclay, CNRS, Institut des Sciences Moléculaires d’Orsay; Arnaud Machelart – Researcher, Université de Lille, CNRS, INSERM, CHU de Lille, Institut Pasteur de Lille; Amine Pochet – PhD student, Université de Lille, CNRS, INSERM, CHU de Lille, Institut Pasteur de Lille
