(306) Polyelectrolyte Complexes as Versatile Vehicles for the Controlled Release of Cefazolin.
Introduction: Controlled release of hydrophilic drugs remains a major challenge in drug delivery, particularly for localized therapeutic applications. This study explores polyelectrolyte complexes (PECs) for sustained cefazolin (Cfz) release to prevent post-surgical infections [1]. By leveraging the inherent properties of PE and optimizing formulation pathways, we aim to address the limitations of conventional drug delivery systems and improve therapeutic outcomes. This approach should allow to reduce the dosing frequency, improve treatment outcomes and ultimately minimize antibioresistance.
Learning Objectives:
Understand the role of polyelectrolytes complexes in designing controlled-release systems.
Tuning the balance of hydrophobic and electrostatic interactions through the formulation pathway.
Evaluate the potential of PEC systems for addressing challenges in hydrophilic drug delivery.
