(312) Biodistribution, Pharmacokinetics and Acute Toxicity of Disulfide Crosslinked P(AAm-co-MAA) Nanogels
Introduction: Unique physicochemical attributes like nano size, highly tunable, pH responsiveness, and hydrophilicity make Poly(acrylamide-co-methacrylic acid) (P(AAm-co-MAA) nanogels a potential nanocarrier system for a range of biomedical applications. For the potential translation of P(AAm-co-MAA) Nanogel as platform delivery system, we present the first pharmacokinetics (PK), biodistribution (BD), and toxicity study of disulfide crosslinked P(AAm-co-MAA) Nanogel, offering similar biodegradation but distinct biodistribution over previously evaluated disulfide bridge containing polymer drug conjugates.
Learning Objectives:
Establish the feasibility of PK, BD of P(AAm-co-MAA) Nanogels in healthy mice.
Influence of administration route (IV, IP, IT) on pharmacokinetic, tissue distribution of Nanogels.
Acute toxicity and compatibility of P(AAm-co-MAA) Nanogels in-vivo following IV, IP, and IP routes.
