(313) Tiny Particles, Big Plans: Nanoparticles for Controlling Drug Transfer through the Placental Barrier

Introduction: Drug delivery during pregnancy presents unique challenges due to the blood-placental barrier (BPB) and risks of fetal exposure. While some treatments require drugs to cross the placenta for fetal therapy, others need to be restricted to maternal circulation. This study investigates how surface-modified gold nanoparticles can be engineered to either cross or be excluded from the placental barrier, enabling more targeted and safer therapeutic approaches during pregnancy.