(316) Lipidic Nanoparticle for Brain-targeted Treatment in Bacterial Meningitis
Introduction: Bacterial meningitis (BM) is a critical, life-threatening infection characterized by inflammation of the meninges and the protective membranes surrounding the central nervous system, necessitating immediate diagnosis and intervention 1. This inflammation spreads across the subarachnoid region of the spinal cord and brain. Due to the limited penetration of several antibacterial agents through the blood-brain barrier, the mortality rate of bacterial meningitis is high. Therapeutic strategies previously employed for the treatment of bacterial meningitis included penicillin and cephalosporins 2.
Learning Objectives:
Synthesis and physicochemical characterization of the transferrin-conjugated ceftriaxone SLNPs.
To evaluate the in vitro antibacterial and anti-biofilm activity against test organisms.
To evaluate the in vivo therapeutic efficacy in a bacterial meningitis-induced mouse model.
