(318) Phenylboronic acid functionalized poly (lactic-co-glycolic acid) nanoparticles towards lung cancer

Introduction: Lung cancer is the leading cause of death among all types of cancer, with a death severity of 350 per day in the United States [1]. The multiple anti-cancer activities of BCA and LTB make an ideal chemo-herbal combination that can synergize the activities and reduce the side effects [2]. Phenylboronic acid (PBA) has been studied more because it targets ubiquitous biomarkers (sialic acid) in lung cancer patients [3]. PBA-functionalized poly (lactic-co-glycolic acid) (PLGA) can be an attractive biomaterial owing to its biocompatibility, cancer specificity, and sustained drug characteristics [4]