(320) Engineered Nanobubbles for Inducing Unprogrammed Necrosis in Cancer Immunortherapy

Introduction: Programmed cell deaths play a key role in the modulation of inflammatory responses by releasing various immunostimulatory molecules. In particular, accidental necrosis can activate eosinophils by releasing interleukin-33 (IL-33), and thereby provide an exceptional opportunity for the recruitment of natural killer cells and cytotoxic T-cells in the antitumor immune response. In this research, we designed nanobubbles that are cavitated by ultrasound to induce cell death, which also dramatically leaks IL-33 and damage-associated molecular patterns (DAMPs).