(321) Biodynamers, dynamic protein nanorods, potentiate antibiotics via membrane interactions
Introduction: Innovative strategies are emerging to overcome the limitations of current medications, such as limited bioavailability. Peptides and poly-amino acids hold great promise due to their biocompatibility, biodegradability, and versatility from amino acid combinations. In particular, these polymers exhibit biological activities, including membrane permeation, driven by their secondary structures and amino acid compositions (1). In this study, we highlight the antibiotic-potentiating effects of newly designed dynamic poly-arginine, so-called Arg-biodynamer, as a novel class of biofunctional polymers.
Learning Objectives:
Biodynamers are poly-amino acids connected by constitutional dynamic chemistry.
Biodynamers are biocompatible, and bacterial membrane selective by secondary structure changes.
Optimized biodynamers boost antibiotics 256-fold and expand their activity across bacterial strains.
