(328) Engineering Extended-Release Profiles for Biologics via Crosslinking of Poloxamer 407 Hydrogels

Introduction: Biologic drugs, such as peptides, proteins, and antibodies, often require high and frequent dosing, leading to side effects and increased costs. To enhance their efficacy and administration, we developed crosslinked thermoresponsive hydrogels using acrylate-modified Poloxamer 407 and thiol-terminated polyethylene glycol. These hydrogels exhibit reversible thermal properties, transitioning from liquid to gel at body temperature, enabling prolonged and controlled release of biologics, thereby offering significant potential for improved drug delivery strategies.