(331) 1-Min Nanocrystals: A Fast, Cost-Effective and Efficient Technique to Mill Drugs Using Speed Mixer

Introduction: The advancement of drug delivery systems has revolutionised pharmaceutical research, especially for poorly water-soluble drugs. Nanocrystals (NCs) are a promising solution, as reducing particle size (PS) enhances bioavailability [1]. However, traditional methods often require lengthy processing times, from hours to days. This study demonstrates dual asymmetric centrifugation (DAC) as a fast, simple, and cost-effective method to produce drug NCs in 1 min, achieving good PS and crystalline properties. It provides a valuable alternative for lab-scale PS reduction in early drug development stages.